cytosine arabinoside造句

• Cytosine arabinoside also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis.
• Cytosine arabinoside interferes with the synthesis of DNA . It is an antimetabolic agent with the chemical name of " 1?-arabinofuranosylcytosine ".
• Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase ( synthesis of DNA ).
• Complete cure is rare with lymphoma and treatment tends to be cytosine arabinoside, and mitoxantrone are sometimes used in the treatment of lymphoma by themselves or in substitution for other drugs.
• Mutations in the CTP synthase have been seen to confer resistance to cytotoxic drugs such as cytosine arabinoside ( ara-C ) in a Chinese hamster ovary ( CHO ) cell model of leukemia though such mutations were not found in human patients with ara-C resistance.